diff --git a/editor/editor_settings.cpp b/editor/editor_settings.cpp
index 1820804cfeb..70f43e01cfe 100644
--- a/editor/editor_settings.cpp
+++ b/editor/editor_settings.cpp
@@ -411,6 +411,7 @@ void EditorSettings::_load_defaults(Ref<ConfigFile> p_extra_config) {
 	_initial_set("interface/editor/automatically_open_screenshots", true);
 	EDITOR_SETTING_USAGE(Variant::BOOL, PROPERTY_HINT_NONE, "interface/editor/single_window_mode", false, "", PROPERTY_USAGE_DEFAULT | PROPERTY_USAGE_RESTART_IF_CHANGED)
 	_initial_set("interface/editor/hide_console_window", false);
+	_initial_set("interface/editor/mouse_extra_buttons_navigate_history", true);
 	_initial_set("interface/editor/save_each_scene_on_quit", true); // Regression
 
 	// Inspector
diff --git a/editor/plugins/script_editor_plugin.cpp b/editor/plugins/script_editor_plugin.cpp
index 07e4d4ebf04..6922a48a503 100644
--- a/editor/plugins/script_editor_plugin.cpp
+++ b/editor/plugins/script_editor_plugin.cpp
@@ -2750,6 +2750,29 @@ void ScriptEditor::drop_data_fw(const Point2 &p_point, const Variant &p_data, Co
 	}
 }
 
+void ScriptEditor::input(const Ref<InputEvent> &p_event) {
+	// This is implemented in `input()` rather than `unhandled_input()` to allow
+	// the shortcut to be used regardless of the click location.
+	// This feature can be disabled to avoid interfering with other uses of the additional
+	// mouse buttons, such as push-to-talk in a VoIP program.
+	if (EDITOR_GET("interface/editor/mouse_extra_buttons_navigate_history")) {
+		const Ref<InputEventMouseButton> mb = p_event;
+
+		// Navigate the script history using additional mouse buttons present on some mice.
+		// This must be hardcoded as the editor shortcuts dialog doesn't allow assigning
+		// more than one shortcut per action.
+		if (mb.is_valid() && mb->is_pressed() && is_visible_in_tree()) {
+			if (mb->get_button_index() == MOUSE_BUTTON_XBUTTON1) {
+				_history_back();
+			}
+
+			if (mb->get_button_index() == MOUSE_BUTTON_XBUTTON2) {
+				_history_forward();
+			}
+		}
+	}
+}
+
 void ScriptEditor::unhandled_key_input(const Ref<InputEvent> &p_event) {
 	ERR_FAIL_COND(p_event.is_null());
 
@@ -3294,7 +3317,6 @@ void ScriptEditor::_bind_methods() {
 	ClassDB::bind_method("_update_script_connections", &ScriptEditor::_update_script_connections);
 	ClassDB::bind_method("_help_class_open", &ScriptEditor::_help_class_open);
 	ClassDB::bind_method("_live_auto_reload_running_scripts", &ScriptEditor::_live_auto_reload_running_scripts);
-
 	ClassDB::bind_method("_update_members_overview", &ScriptEditor::_update_members_overview);
 	ClassDB::bind_method("_update_recent_scripts", &ScriptEditor::_update_recent_scripts);
 
@@ -3427,9 +3449,11 @@ ScriptEditor::ScriptEditor(EditorNode *p_editor) {
 	ED_SHORTCUT("script_editor/window_sort", TTR("Sort"));
 	ED_SHORTCUT("script_editor/window_move_up", TTR("Move Up"), KEY_MASK_SHIFT | KEY_MASK_ALT | KEY_UP);
 	ED_SHORTCUT("script_editor/window_move_down", TTR("Move Down"), KEY_MASK_SHIFT | KEY_MASK_ALT | KEY_DOWN);
-	ED_SHORTCUT("script_editor/next_script", TTR("Next Script"), KEY_MASK_CMD | KEY_MASK_SHIFT | KEY_PERIOD); // these should be KEY_GREATER and KEY_LESS but those don't work
+	// FIXME: These should be `KEY_GREATER` and `KEY_LESS` but those don't work.
+	ED_SHORTCUT("script_editor/next_script", TTR("Next Script"), KEY_MASK_CMD | KEY_MASK_SHIFT | KEY_PERIOD);
 	ED_SHORTCUT("script_editor/prev_script", TTR("Previous Script"), KEY_MASK_CMD | KEY_MASK_SHIFT | KEY_COMMA);
-	set_process_unhandled_key_input(true);
+	set_process_input(true);
+	set_process_unhandled_input(true);
 
 	file_menu = memnew(MenuButton);
 	file_menu->set_text(TTR("File"));
diff --git a/editor/plugins/script_editor_plugin.h b/editor/plugins/script_editor_plugin.h
index 76206055707..6d9b27e0bec 100644
--- a/editor/plugins/script_editor_plugin.h
+++ b/editor/plugins/script_editor_plugin.h
@@ -418,6 +418,7 @@ class ScriptEditor : public PanelContainer {
 	bool can_drop_data_fw(const Point2 &p_point, const Variant &p_data, Control *p_from) const;
 	void drop_data_fw(const Point2 &p_point, const Variant &p_data, Control *p_from);
 
+	virtual void input(const Ref<InputEvent> &p_event) override;
 	virtual void unhandled_key_input(const Ref<InputEvent> &p_event) override;
 
 	void _script_list_gui_input(const Ref<InputEvent> &ev);