diff --git a/scene/main/viewport.cpp b/scene/main/viewport.cpp
index fe82fed2f7d..8412799f5d7 100644
--- a/scene/main/viewport.cpp
+++ b/scene/main/viewport.cpp
@@ -527,6 +527,11 @@ void Viewport::_process_picking() {
 	if (to_screen_rect != Rect2i() && Input::get_singleton()->get_mouse_mode() == Input::MOUSE_MODE_CAPTURED) {
 		return;
 	}
+	if (!gui.mouse_in_viewport) {
+		// Clear picking events if mouse has left viewport.
+		physics_picking_events.clear();
+		return;
+	}
 
 	_drop_physics_mouseover(true);